Slc26a9 is inhibited by the R-region of CFTR via the STAS domain
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چکیده
1 Slc26a9 is inhibited by the R-region of CFTR via the STAS domain Min-Hwang Chang, Consuelo Plata, Aleksandra Sinđić , Wasantha K. Ranatunga, An-Ping Chen, Kambiz Zandi-Nejad, Kim W. Chan, James Thompson, David B. Mount, Michael F. Romero § Physiology & Biophysics, Case Western Reserve University, Cleveland, OH 44106 Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905 USA Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México 14000 Renal Div, Brigham & Women’s Hospital, Boston, MA, 02115; 5 Renal Div, VA Boston Healthcare System, W Roxbury MA, 02132 equal contribution current address: Physiology, Croatian Institute for Brain Research, University of Zagreb, Zagreb, Croatia current address: Pharmacological Sciences, CV Therapeutics, Palo Alto, CA 94304
منابع مشابه
Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain.
SLC26 proteins function as anion exchangers, channels, and sensors. Previous cellular studies have shown that Slc26a3 and Slc26a6 interact with the R-region of the cystic fibrosis transmembrane conductance regulator (CFTR), (R)CFTR, via the Slc26-STAS (sulfate transporter anti-sigma) domain, resulting in mutual transport activation. We recently showed that Slc26a9 has both nCl(-)-HCO(3)(-) exch...
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